Model-Based Approach to Predict Adherence to Protocol During Antiobesity Trials

Model‐Based Approach to Predict Adherence to Protocol During Antiobesity Trials

Development of antiobesity drugs is continuously challenged by high dropout rates during clinical trials. The objective was to develop a population pharmacodynamic model that describes the temporal changes in body weight, considering disease progression, lifestyle intervention, and drug effects. Markov modeling (MM) was applied for quantification and characterization of responder and nonrespond...

non-corrective approach to pronunciation

the aim of this study has been to find answers for the following questions: 1. what is the effect of immediate correction on students pronunciation errors? 2. what would be the effect of teaching the more rgular patterns of english pronunciation? 3. is there any significant difference between the two methods of dealing with pronuciation errore, i. e., correction and the teaching of the regular ...

Developing a Fuzzy Logic Model to Predict Asphaltene Precipitation during Natural Depletion based on Experimental Data

Maximising adherence to study protocol within pharmaco-rehabilitation clinical trials

Background The Dopamine Augmented Rehabilitation in Stroke (DARS) trial is a double-blind placebo controlled trial investigating impact of co-careldopa/placebo in combination with routine NHS occupational/physical therapy on functional outcome in people with acute stroke. The trial involves participants taking Investigational Medicinal Product (IMP)/placebo prior to therapy sessions while in th...

Evaluating a model to predict protocol performance.

BACKGROUND A test protocol is created when individual tests are combined. Even with a few tests, many different protocols are possible. Often, the clinician must select a protocol without information as to the performance of the possible protocols. A model to predict protocol performance could help in this selection process. PURPOSE To evaluate the validity and accuracy of a mathematical mode...